About this item
This antibody recognizes the L1 or Calprotectin molecule, an intra-cytoplasmic antigen comprising of a 12 kDa alpha chain and a 14 kDa beta chain expressed by granulocytes, monocytes and by tissue macrophages. Macrophages usually arise from hematopoietic stem cells in the bone marrow. Under migration into tissues, the monocytes undergo further differentiation to become multifunctional tissue macrophages. They are classified into normal and inflammatory macrophages. Normal macrophages include macrophages in connective tissue (histiocytes), liver (Kupffer's cells), lung (alveolar macrophages), lymph nodes (free and fixed macrophages), spleen (free and fixed macrophages), bone marrow (fixed macrophages), serous fluids (pleural and peritoneal macrophages), skin (histiocytes, Langerhans's cell) and in other tissues. Inflammatory macrophages are present in various exudates. Macrophages are part of the innate immune system, recognizing, engulfing and destroying many potential pathogens including bacteria, pathogenic protozoa, fungi and helminthes. This MAb reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and has been shown as an important marker for identifying macrophages in tissue sections.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Type: Primary
Antigen: S100A8 & S100A9
Clonality: Monoclonal
Clone: Clone MAC387
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Baboon, Cat, Cow, Dog, Goat, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
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Specifications
- Catalog No:
- 75882-858
- 75882-856
- Antigen name:
- Calgranulin B / MRP-8/-14 / MAC 387 / S100A8/A9 / Macrophage Ag
- Calgranulin B / MRP-8/-14 / MAC 387 / S100A8/A9 / Macrophage Ag
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- MAC387
- MAC387
- Host:
- Mouse
- Mouse
- Gene ID:
- Unigene ID: 416073 (S100A8/Calgranulin A/MRP-8) , 112405 (S100A9/Calgranulin B/MRP-14)
- Unigene ID: 416073 (S100A8/Calgranulin A/MRP-8) , 112405 (S100A9/Calgranulin B/MRP-14)
- Isotype:
- IgG1 kappa
- IgG1 kappa