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Specifications
- Antibody type:Primary
- Antigen name:CD357 (GITR) (DTA-1)
- Clonality:Monoclonal
- Clone:DTA-1
- Host:Rat
- Isotype:IgG2b
- Reactivity:Mouse
- Antigen symbol:TNFRSF18
- Flow cytometry:Yes
- Size:500 μg
- Format:SAFIRE Purified
- Form:liquid
- Antigen synonyms:TNFRSF18|AITR
- Cat. no.:75843-358
- Supplier No.:39612-25-500
Specifications
About this item
The DTA-1 monoclonal antibody specifically reacts with MouseGlucocorticoid-Induced TNFR-related protein, also known as GITR and TNFRSF18, a 66-70 kDa homodimer glycoprotein, detected in the T cells treated with glucocorticoid dexamethasone. GITR is also expressed in naïve mice by CD25+/CD4+/CD8a- thymocytes and on CD25+/CD4+/CD45RB-low splenocytes. Low levels were detected in splenic CD25+/CD4+/CD45RB-low T cells, B cells, dendritic cells and macrophages. A GITR ligand was detected on dendritic cells, macrophages and B cells.The DTA-1 antibody stimulates GITR and abrogates suppression by T regulatory cells (Treg), without affecting their proliferation. DTA-1 administration or the removal of GITR-expressing cells led to organ specific autoimmune disease.
Type: Primary
Antigen: TNFRSF18
Clonality: Monoclonal
Clone: DTA-1
Conjugation:
Epitope:
Host: Rat
Isotype: IgG2b
Reactivity: Mouse