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Specifications
- Antibody type:Primary
- Antigen name:Tumor Necrosis Factor alpha
- Clonality:Monoclonal
- Clone:MAb11
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Human
- Antigen symbol:TNFA
- Flow cytometry:Yes
- Size:500 μg
- Form:liquid
- Antigen synonyms:Tumor Necrosis Factor alpha|DIF|Differentiation inducing factor|MCF|Necrosin|TNFSF2|Cachectin|Macrophage cytotoxic factor
- Cat. no.:75841-382
- Supplier No.:84421-20-500
Specifications
About this item
The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.
Type: Primary
Antigen: TNFA
Clonality: Monoclonal
Clone: MAb11
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human