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Specifications
- Antibody type:Primary
- Antigen name:Killer cell Lectin-like Receptor G1
- Clonality:Monoclonal
- Clone:2F1
- Host:Golden syrian hamster
- Isotype:IgG
- Reactivity:Mouse
- Antigen symbol:KLRG1
- Conjugation:APC (Allophycocyanin)
- Flow cytometry:Yes
- Size:25 μg
- Form:liquid
- Antigen synonyms:MAFA|CLEC15A
- Cat. no.:75843-588
- Supplier No.:82112-80-25
Specifications
About this item
The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 (KLRG1), a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA (Mast cell Function-associated Antigen). The antigen contains a cytoplasmic motif similar to ITIM (the immunoreceptor tyrosine-based inhibitory motif). KLRG1 is a receptor for cadherin, a family of transmembrane glycoproteins that mediate cell adhesion, and a common marker of T cell senescence. The receptor is believed to play an important role in the innate and adaptive immune system through the regulation of leukocytes. It is expressed on lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, a sub-set of natural killer (NK) cells, T cells. In NK cells, it inhibits cytokine production and cytotoxicity activity.The receptor expression was not detected on the mouse peritoneal mast cells, or bone marrow mast cells.
Type: Primary
Antigen: KLRG1
Clonality: Monoclonal
Clone: 2F1
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Golden Syrian Hamster
Isotype: IgG
Reactivity: Mouse