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Specifications
- Antibody type:Primary
- Antigen name:IL-17A
- Clonality:Monoclonal
- Clone:17B7
- Host:Rat
- Isotype:IgG2a kappa
- Reactivity:Mouse
- Antigen symbol:IL-17A
- Conjugation:PE (Phycoerythrin)
- Flow cytometry:Yes
- Size:50 μg
- Form:liquid
- Antigen synonyms:CTLA-8|Interleukin-17A|Cytotoxic T-lymphocyte-associated antigen 8
- Cat. no.:75842-500
- Supplier No.:73812-60-50
Specifications
About this item
The 17B7 monoclonal antibody specifically binds to mouse and rat IL-17A, a pro-inflammatory cytokine. It is produced by T helper 17 (Th17) cells, a unique subset of IL-23 dependent CD4+ T cells. Interleukin-17A is highly expressed in transplant rejection, asthma, psoriasis, and multiple sclerosis, and enhances the expression of ICAM-1 in human fibroblasts. The homodimer is expressed by activated peripheral CD4+ T lymphocytes. The Interleukin-17A binds to the IL-17 receptors (IL-17R) expressed by mast cells, monocytes and macrophages, fibroblasts, and endothelial and epithelial cells.
Type: Primary
Antigen: IL-17A
Clonality: Monoclonal
Clone: 17B7
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Rat
Isotype: IgG2a, kappa
Reactivity: Mouse