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Specifications
- Antibody type:Primary
- Antigen name:CD86 (B7-2) (GL-1)
- Clonality:Monoclonal
- Clone:GL-1 (GL1)
- Host:Rat
- Isotype:IgG2a kappa
- Reactivity:Mouse
- Antigen symbol:CD86 (B7-2) (GL-1)
- Flow cytometry:Yes
- Size:100 μg
- Form:liquid
- Antigen synonyms:B70|Ly-58|B7-2
- Cat. no.:75842-992
- Supplier No.:08912-20-100
Specifications
About this item
The GL-1 monoclonal antibody reacts specifically with the mouse B7-2 (also known as CD86), a costimulatory molecule expressed by B and T lymphocytes, macrophages (thioglycollate-induced from peritoneum), astrocytes and dendritic cells. The memory CD4+ T lymphocytes express CD86 (as mRNA and protein). CD86, and the B7-1 (CD 80) molecule, are ligands for CD152 and CD28, and influence the costimulatory interactions between lymphocytes B and T. B7-2 is also involved in the mouse natural killer cell-mediated cytotoxicity. The GL-1 antibody blocks the mixed lymphocyte reaction (MLR) and inhibits the T-cells stimulation by antigen-presenting cells. Mixtures of anti-B7-1 antibody and GL-1 were reported to inhibit the interaction between CD125 and its ligand with the in vivo priming of cytotoxic T lymphocytes.
Type: Primary
Antigen: CD86 (B7-2) (GL-1)
Clonality: Monoclonal
Clone: GL-1 (GL1)
Conjugation:
Epitope:
Host: Rat
Isotype: IgG2a, kappa
Reactivity: Mouse