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Specifications
- Antibody type:Primary
- Antigen name:CD86
- Clonality:Monoclonal
- Clone:IT2.2
- Host:Mouse
- Isotype:IgG2b kappa
- Reactivity:Human
- Antigen symbol:CD86
- Flow cytometry:Yes
- Size:500 μg
- Format:SAFIRE Purified
- Form:liquid
- Antigen synonyms:B70|B7.2
- Cat. no.:75842-986
- Supplier No.:08911-25-500
Specifications
About this item
The IT2.2 antibody reacts with human CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.The IT2.2 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells. It is reported to be cross-reactive with Rhesus, Cynomolgus and Common marmoset CD86.
Type: Primary
Antigen: CD86
Clonality: Monoclonal
Clone: IT2.2
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human