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Specifications
- Antibody type:Primary
- Antigen name:CD80 (B7-1) (16-10A1)
- Clonality:Monoclonal
- Clone:16-10A1
- Host:Armenian hamster
- Isotype:IgG
- Reactivity:Mouse
- Antigen symbol:CD80 (B7-1) (16-10A1)
- Flow cytometry:Yes
- Size:100 μg
- Format:SAFIRE Purified
- Form:liquid
- Antigen synonyms:Ly-53|B7-1|B7
- Cat. no.:75843-716
- Supplier No.:02912-25-100
Specifications
About this item
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Type: Primary
Antigen: CD80 (B7-1) (16-10A1)
Clonality: Monoclonal
Clone: 16-10A1
Conjugation:
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse