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Specifications
- Antibody type:Primary
- Antigen name:CD44 antigen
- Clonality:Monoclonal
- Clone:IM7
- Host:Rat
- Isotype:IgG2b kappa
- Reactivity:Human
- Antigen symbol:CD44
- Conjugation:APC (Allophycocyanin)
- Flow cytometry:Yes
- Size:100 μg
- Form:liquid
- Antigen synonyms:Hermes|HUTCH-1|H-CAM|ECMR III|Pgp-1|Hyaluronate receptor|Ly-24
- Cat. no.:75841-838
- Supplier No.:06511-80-100
Specifications
About this item
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes. 
Type: Primary
Antigen: CD44
Clonality: Monoclonal
Clone: IM7
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Rat
Isotype: IgG2b, kappa
Reactivity: Human