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Specifications
- Antibody type:Primary
- Clonality:Monoclonal
- Clone:145-2C11
- Host:Armenian hamster
- Isotype:IgG
- Reactivity:Mouse
- Antigen symbol:CD3e
- Conjugation:PE (Phycoerythrin)
- Flow cytometry:Yes
- Size:500 μg
- Form:liquid
- Antigen synonyms:T3|CD3 epsilon
- Cat. no.:75841-736
- Supplier No.:05122-60-500
Specifications
About this item
The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex. Together with the γ and δ subunits of CD3, the ε subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the ε chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.
Type: Primary
Antigen: CD3e
Clonality: Monoclonal
Clone: 145-2C11
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse