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Specifications
- Antibody type:Primary
- Clonality:Monoclonal
- Clone:CD28.2
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Human
- Antigen symbol:CD28
- Flow cytometry:Yes
- Size:500 μg
- Format:SAFIRE Purified
- Form:liquid
- Antigen synonyms:Tp44|T44
- Cat. no.:75844-272
- Supplier No.:10311-25-500
Specifications
About this item
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
Type: Primary
Antigen: CD28
Clonality: Monoclonal
Clone: CD28.2
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human