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Specifications
- Antibody type:Primary
- Antigen name:Cytotoxic T Lymphocyte-Associated Antigen 4
- Clonality:Monoclonal
- Clone:UC10-4F10-11
- Host:Armenian hamster
- Isotype:IgG
- Reactivity:Mouse
- Antigen symbol:CTLA4
- Conjugation:PE (Phycoerythrin)
- Flow cytometry:Yes
- Size:25 ug
- Form:liquid
- Antigen synonyms:Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4)|Ly-56
- Cat. no.:75842-244
- Supplier No.:14612-60-25
Specifications
About this item
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
Type: Primary
Antigen: CTLA4
Clonality: Monoclonal
Clone: UC10-4F10-11
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse