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Specifications
- Antibody type:Primary
- Clonality:Monoclonal
- Clone:M1/70
- Host:Rat
- Isotype:IgG2b kappa
- Reactivity:Human
- Antigen symbol:CD11b
- Conjugation:APC (Allophycocyanin)
- Flow cytometry:Yes
- Size:100 ug
- Form:liquid
- Antigen synonyms:C3biR|Mo1|CR3|Mac-1|Ly-40|ITGAM
- Cat. no.:75842-798
- Supplier No.:03221-80-100
Specifications
About this item
The M1/70 monoclonal antibody specifically reacts with the 170 kDa αM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18). Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.
Type: Primary
Antigen: CD11b
Clonality: Monoclonal
Clone: M1/70
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Rat
Isotype: IgG2b, kappa
Reactivity: Human