MethElute™ Reagent (TMPAH) ideally suits for the quantitative methylation and detection of barbiturates, sedatives, xanthine bases, phenolic alkaloids, and phenytoin, giving a single quantitative peak for each substance.

• Highly precise, with coefficient of variation of 5% or less
• High sensitivity
• Barbiturates detected down to 0.2 mg/dl
• Accuracy is similar or better than the UV/TLC method

When the reagent is heated with drug-containing extracts, serum, or urine the drugs containing reactive amino, hydroxyl, and carboxyl functions will be methylated at the reactive sites. Accuracy comparable or better than the UV/TLC method (GC is superior to UV/TLC when phenobarbitol and phenytoin present).

Hazards: Flammable, toxic.

Standard components: Trimethylanilinium hydroxide in methanol
Standard concentration: 0.2 M