About this item
The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will compete for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.
Type: Primary
Antigen: CD4
Clonality: Monoclonal
Clone: RM4-5
Conjugation: PE (Phycoerythrin)rCP
Epitope:
Host: Rat
Isotype: Rat IgG2a, kappa
Reactivity: Mouse
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Specifications
- Catalog No:
- 76040-302
- 76040-304
- Antigen name:
- CD4
- CD4
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- RM4-5
- RM4-5
- Host:
- Rat
- Rat
- Gene ID:
- 12504
- 12504
- Isotype:
- IgG2a kappa
- IgG2a kappa