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Specifications
- Protein/peptide type:Recombinant
- Source:Insect cells (Sf21)
- Species:Human
- Size:2 μg
- Tag sequence:His Tag
- Storage conditions:Stable for at least 6 months after receipt when stored at −80 °C.
- Biological activity:~200-300ng are required for standard HAT assay.
- Protein synonyms:Lysine Acetyltransferase 2A|STAF97|GCN5L2|Histone Acetyltransferase KAT2A|Histone Acetyltransferase GCN5
- Protein/peptide name:GCN5 highly active
- Purity:>95% (SDS-PAGE)
- Formulation:Liquid, In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
- Cat. no.:75794-156
- Supplier No.:90-345
Specifications
About this item
GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4.
- Fusion-Tag: His Tag
This recombinant proteins is for research use only.