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Specifications
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:10 μg
- Tag sequence:DDDDK Tag
- Storage conditions:Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:Pre-B Cell Colony Enhancing Factor 1|Nicotinamide Phosphoribosyltransferase|PBEF1
- Protein/peptide name:NAMPT
- Purity:>95% (SDS-PAGE)
- Sequence:1-491
- Formulation:Lyophilized, Contains PBS.
- Cat. no.:75793-542
- Supplier No.:90-018
Specifications
About this item
Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
- Fusion-Tag: DDDDK Tag
This recombinant proteins is for research use only.