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Specifications
- Protein/peptide type:Recombinant
- Species:Mouse
- Size:0.05 mg
- Tag sequence:C-Fc tag
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Endotoxin content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Protein synonyms:activin A receptor|Activin receptor-like kinase 1|ACVRL1|SKR3|ALK-1|activin A receptor type II-like 1|TSR-I|Serine/threonine-protein kinase receptor R3|TGF-B superfamily receptor type I
- Protein/peptide name:ALK1
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:38.1 kD
- Sequence:Asp23-Pro119
- Formulation:Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Cat. no.:75791-692
- Supplier No.:92-565
Specifications
About this item
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF- beta superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.
- Fusion-Tag: C-Fc tag
This recombinant protein can be used for biological assays. For research use only.