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Specifications
- Protein/peptide type:Recombinant
- Source:Cells
- Species:Human
- Size:0.05 mg
- Tag sequence:C-Fc tag
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Endotoxin content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Protein synonyms:NKRP1A|Killer cell lectin-like receptor subfamily B member 1|NKR-P1A|Natural killer cell surface protein P1A|C-type lectin domain family 5 member B|KLRB1|CLEC5B|HNKR-P1a|CD161
- Protein/peptide name:KLRB1
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:45.6 kD
- Sequence:Gln67-Ser225
- Formulation:Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Cat. no.:75791-502
- Supplier No.:92-466
Specifications
About this item
Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
- Fusion-Tag: C-Fc tag
This recombinant protein can be used for biological assays. For research use only.