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Specifications
- Protein/peptide type:Recombinant
- Species:Human
- Size:0.05 mg
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Endotoxin content:<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
- Protein synonyms:NK cell|Interleukin-12 subunit alpha|Cytotoxic lymphocyte maturation factor 35 kDa subunit|IL-12A|IL-12 subunit p35|IL12A|CLMF p35|NKSF1 stimulatory factor chain 1
- Protein/peptide name:IL12
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:22.5 and 34.7 kD
- Sequence:Arg23-Ser219&Ile23-Ser328
- Formulation:Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
- Cat. no.:75791-312
- Supplier No.:92-363
Specifications
About this item
IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN- gamma ) and tumor necrosis factor-alpha (TNF- alpha) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN- gamma . T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.
This recombinant protein can be used for biological assays. For research use only.