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Specifications
- Antibody type:Primary
- Antigen name:indoleamine 2,3-dioxygenase 1
- Clonality:Polyclonal
- Gene ID:P14902
- Host:Rabbit
- Reactivity:Human
- Antigen symbol:IDO1
- Conjugation:Unconjugated
- ELISA:Yes
- Flow cytometry:Yes
- Size:100 ug
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:IDO1
- Storage buffer:Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
- Storage temperature:Stable for at least 6 months after receipt when stored at –20 °C.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:Recombinant human IDO.
- Tested applications:Immunocytochemistry
- Cat. no.:75793-316
- Supplier No.:36-228
Specifications
About this item
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
ELISA: (direct and indirect: 1:2,000-1:10,000). Flow Cytometry: (1:200-1:500). Immunocytochemistry: (1:500) . Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
Type: Primary
Antigen: IDO1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human