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Specifications
- Antibody type:Primary
- Antigen name:interleukin 1 alpha
- Clonality:Monoclonal
- Clone:Bamboo-2
- Gene ID:P01582
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Mouse
- Antigen symbol:Il1a
- Conjugation:Unconjugated
- ELISA:Yes
- Size:100 ug
- Form:Liquid
- Antigen synonyms:Il1a
- Storage buffer:Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
- Storage temperature:Stable for at least 1 year after receipt when stored at –20 °C.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:Recombinant mouse mature IL-1alpha.
- Purification:>95% (SDS-PAGE)
- Cat. no.:75793-110
- Supplier No.:36-165
Specifications
About this item
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
ELISA: (as a detection antibody).
Type: Primary
Antigen: Il1a
Clonality: Monoclonal
Clone: Bamboo-2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Mouse