About this item
Fluorogenic substrate for caspase 3, cathepsins, plasmins, granzyme B, and more.
- Rhodamine 110 for use as standard for rhodamine 110-based peptidase substrates
- AMC and Rhodamine 110-based protease substrates
Rhodamine 110 and R110-PEG can be used as a reference standard for rhodamine 110-based peptidase substrates.
Z-FR-AMC is a substrate for serine proteases, including cathepsins, kallikrein and plasmin.
Ac-DEVD-AMC is a fluorogenic substrate for caspase 3 and can be used to continuously measure the activity of caspase-3 in cell extracts, using a fluorometer or fluorescence microplate reader.
BZAR is a substrate for serine proteases and is also an inhibitor for quanidinobenzoatase. It is 50 to 100 times more sensitive than the AMC-based substrate.
Ac-IETD-R110 is a substrate for caspase-8, which is involved at the early stage of apoptosis, acting as an initiator of the caspase activation cascade.
Z-FR-R110 is a substrate for the cysteine proteases cathepsins B and L. The substrate has been used in flow cytometry studies of human monocytes and rat macrophages.
D2R is a general substrate for caspases including caspases 3 and 7. Unlike other fluorogenic substrates for caspases, D2R appears to be membrane-permeant, and thus can be used to measure caspase activity in live cells without osmotic shock for flow cytometry studies, as well as for cell extracts.
Z-AAD-R110 is a substrate for granzyme B. Granzyme B from T lymphocytes and natural killer cells induces apoptosis in target cells by activating caspases and causing mitochondrial cytochrome C release.
Z-AA-R110-PEG is a substrate for elastate.
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