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Specifications
- Antibody type:Primary
- Antigen name:Coagulation Factor 13 A1
- Clonality:Polyclonal
- Host:Goat
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:F13A1
- Conjugation:Unconjugated
- Size:100 µg
- Western blot:Yes
- Cross adsorption:No
- Antigen synonyms:coagulation factor XIII A chain|A1 polypeptide)|protein-glutamine gamma-glutamyltransferase A chain|A subunit|coagulation factor XIII|coagulation factor XIIIa|fibrinoligase|FSF|bA525O21.1 (coagulation factor XIII|factor XIIIa|TGase|A polypeptide|fibrin stabilizing factor|transglutaminase. plasma|transglutaminase A chain
- Storage buffer:TBS, pH 7.3, with 0.5% BSA and 0.02% Sodium azide
- Storage temperature:–20 °C, avoid freeze/thaw cycles
- Cat. no.:CAPIPA5-18806
- Supplier No.:PA5-18806
Specifications
About this item
This antibody is predicted to react with mouse based on sequence homology. This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Recommended Dilutions: Western Blot: 0.05-0.2 ug/ml
Type: Primary
Antigen: F13A1 (coagulation factor XIII, A1 polypeptide)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Goat
Isotype: none
Reactivity: Human