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Specifications
- Antibody type:Primary
- Antigen name:Casein beta
- Antigen symbol:CASB
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Goat
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western blot:Yes
- Size:100 µg
- Antigen synonyms:ALIEN|COP9 signalosome complex subunit 2|thyroid receptor interacting protein 15|SGN2|subunit 2|CSN2|COP9 constitutive photomorphogenic homolog subunit 2|JAB1-containing signalosome subunit 2|COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)|COP9|COPS2|TRIP15
- Gene ID:COPS2/9318; Cops2/12848
- Storage buffer:TBS, pH 7.3, with 0.5% BSA and 0.02% Sodium azide
- Storage temperature:–20 °C, avoid freeze/thaw cycles
- Cross adsorption:No
- Tested applications:Immunohistochemistry
- Cat. no.:CAPIPA5-18161
- Supplier No.:PA5-18161
Specifications
About this item
This antibody is predicted to react with bovine, canine and rat based on sequence homology. Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Recommended Dilutions: Western Blot: 1-3 ug/ml, Immunohistochemistry: 3-5µg/ml
Type: Primary
Antigen: COPS2 (COP9 signalosome subunit 2)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Goat
Isotype: none
Reactivity: Human, Mouse