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Specifications
- Antibody type:Primary
- Antigen name:Estrogen Receptor
- Clonality:Polyclonal
- Gene ID:ESR2/281146/2100/443066/396697/100346748; Esr2/13983/25149
- Host:Rabbit
- Isotype:IgG
- Reactivity:Pig,Rabbit,Sheep,Human,Bovine,Rat,Mouse
- Antigen symbol:ESR
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Size:500 µL
- Western blot:Yes
- Cross adsorption:No
- Antigen synonyms:estrogen receptor alpha delta 4*,5,6,7*/654 isoform|estradiol receptor|nuclear receptor subfamily 3 group A member 1|estrogen receptor|ER-alpha|estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform|estrogen receptor alpha delta 4 +49 isoform
- Storage buffer:PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium azide
- Storage temperature:4 °C
- Tested applications:Immunohistochemistry (Paraffin)
- Cat. no.:CAPIPA5-16476
- Supplier No.:PA5-16476
Specifications
About this item
This Antibody targets Estrogen Receptor in IF, IHC (P), IP, and WB applications and shows reactivity with mouse, Rabbit, Rat, Bovine, Human, Ovine, and Porcine samples. The immunogen is a synthetic peptide from the N-terminus of human estrogen receptor, alpha protein. Estrogen Receptors (ER) are members of the steroid family of nuclear receptors. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Each protein contains distinct functional domains required for transcriptional activation, binding to estrogen response elements (ERE) in DNA, constitutive dimerization, binding to heat shock proteins, and ligand recognition. ER is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to EREs. When bound to DNA, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are several different isoforms of both ER alpha and ER beta. ER is an important regulator of growth and differentiation in the mammary gland. The presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e. g. tamoxifen) therapy.
Recommended Dilutions: Western Blot: 2.5-5.0 µg/ml, Immunofluorescence: 1:50-1:200, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 10-20 µg/mL, Immunoprecipitation: 10 µg/ml
Type: Primary
Antigen: ESR1 (estrogen receptor 1)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: