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Specifications
- Antibody type:Primary
- Antigen name:Receptor tyrosine-protein kinase erbB-2
- Clonality:Polyclonal
- Gene ID:ERBB2/2064; Erbb2/13866/24337
- Host:Rabbit
- Isotype:IgG
- Reactivity:Primates,Human,Rat,Mouse
- Antigen symbol:HER2
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Size:500 µL
- Western blot:Yes
- Cross adsorption:No
- Antigen synonyms:herstatin|NEU|MLN19|Tyrosine kinase-type cell surface receptor HER2|c-erb B2/neu protein|MLN 19|CD340|Metastatic lymph node gene 19 protein|p185erbB2|Proto-oncogene c-ErbB-2|Proto-oncogene Neu|metas|NGL
- Storage buffer:PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium azide
- Storage temperature:4 °C
- Tested applications:Immunohistochemistry (Paraffin)
- Cat. no.:CAPIPA5-16305
- Supplier No.:PA5-16305
Specifications
About this item
This Antibody targets HER-2 in IHC (P), IP, and WB applications and shows reactivity with mouse, Non-human primate, Rat, and Human samples. The immunogen is synthetic peptide derived from C-terminus of human c-erbB-2/HER-2 protein. This Sequence is identical in rat neu protein. This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Recommended Dilutions: Western Blot: 5-10 µg/mL, Immunohistochemistry (Paraffin): 2.5-5.0 µg/ml, Immunoprecipitation: 10 µg/ml
Type: Primary
Antigen: ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: