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Specifications
- Antibody type:Primary
- Antigen name:Interleukin 12 Beta
- Clonality:Polyclonal
- Host:Goat
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:IL12B
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:100 µg
- Western blot:Yes
- Cross adsorption:No
- Antigen synonyms:NKSF|NK cell stimulatory factor chain 2|IL12|CLMF|interleukin-12 beta chain|CLMF2|natural killer cell stimulatory factor|NKSF2|interleukin 12|IL-12 subunit p40|CLMF p40|IL-12B|subunit p40|p40|cytotoxic lymphocyte maturation factor 40 kDa subunit|interleukin-12 subunit beta
- Storage buffer:TBS, pH 7.3, with 0.5% BSA and 0.02% Sodium azide
- Storage temperature:–20 °C, avoid freeze/thaw cycles
- Tested applications:Immunohistochemistry
- Cat. no.:CAPIPA5-18740
- Supplier No.:PA5-18740
Specifications
About this item
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis , suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Recommended Dilutions: Western Blot: 0.1-0.3 ug/ml, Immunohistochemistry: 4-6µg/ml
Type: Primary
Antigen: IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Goat
Isotype: none
Reactivity: Human