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Specifications
- Antibody type:Primary
- Antigen name:Proteasome (prosome, macropain) Activator Subunit 1 (PA28 alpha)
- Clonality:Polyclonal
- Host:Goat
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:PSME1
- Conjugation:Unconjugated
- Size:100 µg
- Western blot:Yes
- Cross adsorption:No
- Antigen synonyms:PA28A|11S regulator complex alpha subunit|interferon gamma up-regulated I-5111 protein|activator of multicatalytic protease subunit 1|interferon-gamma-inducible protein 5111|IFI5111|proteasome (prosome|proteasome activator subunit-1|macropain) activator subunit 1 (PA28 alpha)|MGC8628|interferon-gamma IEF SSP 5111|PSME1|proteasome activator subunit 1|PA28alpha|29-kD MCP activator subunit|REGalpha
- Storage buffer:TBS, pH 7.3, with 0.5% BSA and 0.02% Sodium azide
- Storage temperature:–20 °C, avoid freeze/thaw cycles
- Cat. no.:CAPIPA5-18707
- Supplier No.:PA5-18707
Specifications
About this item
This antibody is predicted to react with canine, mouse and rat based on sequence homology. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.
Recommended Dilutions: Western Blot: 0.3-1 ug/ml
Type: Primary
Antigen: PSME1 (proteasome (prosome, macropain) activator subunit 1 (PA28 alpha))
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Goat
Isotype: none
Reactivity: Human