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Specifications
- Antibody type:Primary
- Antigen name:Galanin Receptor 2
- Clonality:Polyclonal
- Host:Goat
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:GALR2
- Conjugation:Unconjugated
- Size:100 µg
- Western blot:Yes
- Cross adsorption:No
- Antigen synonyms:GALNR2|MGC125983|MGC125984
- Storage buffer:TBS, pH 7.3, with 0.5% BSA and 0.02% Sodium azide
- Storage temperature:–20 °C, avoid freeze/thaw cycles
- Cat. no.:CAPIPA5-18630
- Supplier No.:PA5-18630
Specifications
About this item
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway , in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
Recommended Dilutions: Western Blot: 0.3-1 ug/ml
Type: Primary
Antigen: GALR2 (galanin receptor 2)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Goat
Isotype: none
Reactivity: Human