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Specifications
- Antibody type:Primary
- Antigen name:Alanyl Aminopeptidase
- ChIP:Yes
- Clonality:Polyclonal
- Gel shift:Yes
- Host:Rabbit
- Isotype:IgG
- Neutralisation:Yes
- Reactivity:Human
- Antigen symbol:ANPEP
- Conjugation:Unconjugated
- ELISA:Yes
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Size:400 µL
- Western blot:Yes
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:Apn|AP-N|Cd13|aminopeptidase M|membrane protein p161|aminopeptidase N|microsomal aminopeptidase|aminopeptidase N/CD13|alanyl aminopeptidase|P150|AP-M
- Storage buffer:PBS with 0.09% Sodium azide
- Molecular weight:109.54 kDa
- Storage temperature:Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at –20 °C
- Concentration:Lot-specific
- Immunogen:KLH conjugated synthetic peptide between 615-641 amino acids from the central region of human ANPEP
- Purification:Ammonium sulfate precipitation, Size-exclusion - Dialysis
- Cat. no.:CAPIPA5-14565
- Supplier No.:PA514565
Specifications
About this item
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
Western Blot: 1:1000
Type: Primary
Antigen: ANPEP
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human