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Specifications
- Antibody type:Primary
- Antigen name:Retinoblastoma Protein
- ChIP:Yes
- Clonality:Polyclonal
- Gel shift:Yes
- Host:Rabbit
- Isotype:IgG
- Neutralisation:Yes
- Reactivity:Human
- Antigen symbol:RB1
- Conjugation:Unconjugated
- ELISA:Yes
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Size:400 µL
- Western blot:Yes
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:RB1|pRb|OSRC|pp110|PP110|P105-RB|RB|Retinoblastoma-associated protein|p105-Rb
- Modification:phospho-Ser780
- Storage buffer:PBS with 0.09% Sodium azide
- Molecular weight:106.16 kDa
- Storage temperature:Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at –20 °C
- Concentration:Lot-specific
- Immunogen:KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S780 of human Rb
- Tested applications:Dot Blot
- Purification:Antigen affinity chromatography
- Cat. no.:CAPIPA5-12681
- Supplier No.:PA512681
Specifications
About this item
This antibody is predicted to react with mouse and rat based on sequence homology. RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
Recommended Dilutions: Immunohistochemistry: 1:50-1:100, Dot blot: 1:500
Type: Primary
Antigen: RB1 (retinoblastoma 1)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human