Anti-PSMC1 Rabbit Polyclonal Antibody

Catalog #: 10451-336

Supplier: Bioss

Catalog #: 10451-336

Supplier: Bioss

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Specifications

Antibody type:
Primary
Antigen name:
Proteasome 26S Subunit, Atpase 1
Clonality:
Polyclonal
Gene ID:
5700
Host:
Rabbit
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Antigen symbol:
PSMC1
Conjugation:
Unconjugated
ImmunoChemistry:
Yes
Size:
100 µg
Western blot:
Yes
Cross adsorption:
No
Form:
liquid
Antigen synonyms:
p56|P26S4|S4
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Storage temperature:
Store at –20 °C for 12 months
Concentration:
1 μg/μl
Shipping temperature:
4°C
Purification:
Purified by Protein A
Cat. no.:
10451-336
Supplier No.:
BS-6627R

Specifications

About this item

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.