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Specifications
- Antibody type:Primary
- Antigen name:DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
- Clonality:Polyclonal
- Gene ID:23586
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Mouse
- Antigen symbol:DDX58
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:100 µg
- Western blot:Yes
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:Probable ATP-dependent RNA helicase DDX58|DEAD box protein 58|RIGI|RIG-I|RIG-1|RLR-1
- Modification:Thr170
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
- Storage temperature:Store at –20 °C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Cat. no.:10412-808
- Supplier No.:BS-5300R
Specifications
About this item
The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200
Type: Primary
Antigen: DDX58
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse