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Specifications
- Antibody type:Primary
- Antigen name:Killer cell lectin-like receptor subfamily B, member 1
- Clonality:Polyclonal
- Gene ID:3820
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:KLRB1
- Conjugation:HRP (Horseradish Peroxidase)
- ImmunoChemistry:Yes
- Size:100 µL
- Western blot:Yes
- Cross adsorption:No
- Form:liquid
- Antigen synonyms:NKRP1A|hNKR-P1A|NKR-P1A|NKR-P1|NKR|CLEC5B|CD161
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:175-225/225
- Purification:Purified by Protein A
- Cat. no.:10354-926
- Supplier No.:BS-2807R-HRP
Specifications
About this item
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500
Type: Primary
Antigen: KLRB1
Clonality: Polyclonal
Clone:
Conjugation: HRP (Horseradish Peroxidase)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human