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Specifications
- Antibody type:Primary
- Antigen name:MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
- Clonality:Polyclonal
- Gene ID:P49959
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:MRE11A
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:0.02 mg
- Western blot:Yes
- Epitope:near the N-Terminus
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:MRE11A
- Storage buffer:MRE11 Antibody is supplied in PBS containing 0.02% sodium azide.
- Molecular weight:Predicted: 78 kDa Observed: 73 kDa
- Storage temperature:MRE11 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:MRE11 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human MRE11. The immunogen is located within amino acids 40 - 90 of MRE11.
- Purification:MRE11 Antibody is affinity chromatography purified via peptide column.
- Cat. no.:10750-764
- Supplier No.:5547_S
Specifications
About this item
MRE11 Antibody: MRE11 is involved in the repair of DNA double strand breaks as part of a complex that includes the Rad50 and NBS1 protein and is thought to act in the same pathway as the A-T mutated (ATM) protein. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for non-homologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Mutations in this protein result in a novel ataxia telangiectasia-like disorder (ATLD). Unlike the ATM protein, MRE11 is necessary proper mammalian development.
Type: Primary
Antigen: MRE11A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat