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Specifications
- Antibody type:Primary
- Antigen name:3-hydroxyanthranilate 3,4-dioxygenase
- Clonality:Polyclonal
- Gene ID:P46952
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:HAAO
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:0.02 mg
- Western blot:Yes
- Epitope:near the N-Terminus
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:HAAO
- Storage buffer:HAAO Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage temperature:HAAO antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:HAAO antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human HAAO. The immunogen is located within amino acids 30 - 80 of HAAO.
- Purification:HAAO Antibody is affinity chromatography purified via peptide column.
- Cat. no.:10750-584
- Supplier No.:5251_S
Specifications
About this item
HAAO Antibody: HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
Type: Primary
Antigen: HAAO
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat