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Specifications
- Antibody type:Primary
- Antigen name:TGF-beta activated kinase 1/MAP3K7 binding protein 2
- Clonality:Polyclonal
- Gene ID:Q9NYJ8
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:TAB2
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:0.02 mg
- Epitope:C-Terminal
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:TAB2
- Storage buffer:TAB2 Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage temperature:TAB2 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2. The immunogen is located within the last 50 amino acids of TAB2.
- Purification:TAB2 Antibody is affinity chromatography purified via peptide column.
- Cat. no.:10749-650
- Supplier No.:3389_S
Specifications
About this item
TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Type: Primary
Antigen: TAB2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human