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Specifications
- Antibody type:Primary
- Antigen name:DNA fragmentation factor, beta subunit
- Clonality:Polyclonal
- Gene ID:O54788
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:Dffb
- Conjugation:Unconjugated
- ELISA:Yes
- Size:0.02 mg
- Western blot:Yes
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:Dffb
- Storage buffer:DFF40 Antibody is supplied in PBS containing 0.02% sodium azide.
- Molecular weight:Predicted: 37 kDa Observed: 38 kDa
- Storage temperature:DFF40 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Shipping temperature:4 °C
- Immunogen:DFF40 antibody was raised against a 16 amino acid peptide near the center of human DFF40. The immunogen is located within amino acids 190 - 240 of DFF40.
- Tested applications:Immunocytochemistry
- Purification:DFF40 Antibody is affinity chromatography purified via peptide column.
- Cat. no.:10749-330
- Supplier No.:2155_S
Specifications
About this item
DFF40 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD for caspase activated deoxyribonuclease. The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN, DFF40, and human CAD, respectively. DFF45/ICAD is the inhibitory protein of DFF40/CAD and forms complex with DFF40/CAD. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death.
Type: Primary
Antigen: Dffb
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat