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Specifications
- Antibody type:Primary
- Antigen name:ubiquilin 4
- Clonality:Polyclonal
- Gene ID:Q9NRR5
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:UBQLN4
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:0.02 mg
- Western blot:Yes
- Epitope:near the N-Terminus
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:UBQLN4
- Storage buffer:CIP75 Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage temperature:CIP75 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:CIP75 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CIP75. The immunogen is located within the first 50 amino acids of CIP75.
- Purification:CIP75 Antibody is affinity chromatography purified via peptide column.
- Cat. no.:10748-814
- Supplier No.:5267_S
Specifications
About this item
CIP75 Antibody: The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.
Type: Primary
Antigen: UBQLN4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat