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Specifications
- Antibody type:Primary
- Antigen name:myeloid cell leukemia sequence 1 (BCL2-related)
- Clonality:Polyclonal
- Gene ID:Q07820
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:MCL1
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoFluorescence:Yes
- Size:0.02 mg
- Western blot:Yes
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:MCL1
- Storage buffer:Mcl-1 Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage temperature:Mcl-1 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:Mcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Mcl-1. The immunogen is located within amino acids 20 - 70 of Mcl-1.
- Tested applications:Immunocytochemistry
- Purification:Mcl-1 Antibody is Ion exchange chromatography purified.
- Cat. no.:10748-462
- Supplier No.:3479_S
Specifications
About this item
Mcl-1 Antibody: Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least three distinct isoforms designated Mcl-1L, Mcl-1S and Mcl-1ES. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.
Type: Primary
Antigen: MCL1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human