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Specifications
- Antibody type:Primary
- Antigen name:DNA fragmentation factor, 45kDa, alpha polypeptide
- Clonality:Polyclonal
- Gene ID:O00273
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:DFFA
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoFluorescence:Yes
- Size:0.02 mg
- Western blot:Yes
- Epitope:near the C-Terminus
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:DFFA
- Storage buffer:DFF45 Antibody is supplied in PBS containing 0.02% sodium azide.
- Molecular weight:45 kDa
- Storage temperature:DFF45 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Shipping temperature:4 °C
- Immunogen:DFF45 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DFF45. The immunogen is located within the last 50 amino acids of DFF45.
- Tested applications:Immunocytochemistry
- Purification:DFF45 Antibody is Antibody is DEAE purified.
- Cat. no.:10748-236
- Supplier No.:1141_S
Specifications
About this item
DFF45 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human 45 kDa DNA fragmentation factor (DFF45) was identified recently which was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD. Upon cleavage of DFF45/ICAD, a caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of DFF45/ICAD, which causes DFF40/CAD activation and DNA degradation, is the hallmark of apoptotic cell death.
Type: Primary
Antigen: DFFA
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human