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Specifications
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:0.1 mg
- Tag sequence:His Tag
- Biological activity:Measured by its binding ability in a functional ELISA Immobilized human HMGB at 2μg/ml (100μl/well) can bind human AGER. The EC50 of human AGER is 0. 22μg/ml.
- Protein synonyms:SBP-1|HMGB1|HMG3|HMG1
- Protein/peptide name:Hmgb1
- Purity:>95% as determined by SDS-PAGE.
- Molecular weight:25.7 kDa
- Formulation:Lyophilized, PBS, pH7.4
- Tested applications:Western Blot
- Cat. no.:10797-434
- Supplier No.:96-393
Specifications
About this item
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.