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Specifications
- Antibody type:Primary
- Antigen name:Cytochrome P450, Family 27, Subfamily B, Polypeptide 1
- Clonality:Polyclonal
- Gene ID:CYP27B1/1594; Cyp27b1/13115
- Host:Rabbit
- Reactivity:Human,Mouse
- Antigen symbol:CYP27B1
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Size:400 µL
- Antigen synonyms:CYP27B|CYP1|P450c1|VDR|VDDR|CYP1alpha|PDDR|VDD1|VDDRI|CP2B
- Storage buffer:PBS with 0.09% Sodium azide
- Immunogen:Synthetic peptide from the C-terminal region of human CYP27B1 conjugated to KLH.
- Cat. no.:CAPIPA526065
- Supplier No.:PA526065
Specifications
About this item
CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
Flow Cytometry: 1:10-1:50, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1000
Type: Primary
Antigen: CYP27B1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse