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Specifications
- Antibody type:Primary
- Antigen name:Presenilin 1
- Clonality:Polyclonal
- Host:Rabbit
- Isotype:IgG
- Antigen symbol:PSEN1
- Conjugation:Unconjugated
- ImmunoFluorescence:Yes
- Size:500 µg
- Western blot:Yes
- Epitope:N-Terminal
- Cross adsorption:No
- Format:Lyophilized
- Antigen synonyms:FAD|Alzheimer Disease 3|Homo Sapiens Clone CC44 Senilin 1|Senilin 1|PS1|PSNL1|AD3|S182 Protein
- Immunogen:A synthetic peptide corresponding to a region (1-20 aa) from the N-terminus of human Presenilin 1 conjugated to Diptheria toxoid.
- Cat. no.:10782-734
- Supplier No.:R-1605-500
Specifications
About this item
Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).
Specificity confirmed by WB and IF using transfected cells, Presenilin 1 knock-out mouse cells, mouse and human brain.
Application Information:
IF and WB. Suggested dilution of 1:2,000 is recommended for WB. On SDS-PAGE, the predominant form detected by this antibody is the N-terminal Presenilin 1 fragment of approx 29 kDa. The uncleaved form of Presenilin 1 migrates to approx 45 kDa. Human and mouse brain samples commonly prepared with reducing agent (50mM DTT), urea (2.3M), SDS (1%) in 62.5 mM Tris-HCl pH 6.8 sample buffer heated to 50C for 15 min. The suggested dilution for IF is 1:100 for acetone or paraformaldehyde fixed cells or tissue. Biosensis recommends that the optimal working dilution should be determined by the end user.
Type: Primary
Antigen: PSEN1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype: IgG
Reactivity: 0