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Specifications
- Antibody type:Primary
- Antigen name:Brain-Derived Neurotrophic Factor
- Clonality:Polyclonal
- Host:Sheep
- Isotype:IgG
- Neutralisation:Yes
- Reactivity:Human,Rat
- Antigen symbol:BDNF
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:500 µg
- Western blot:Yes
- Cross adsorption:No
- Format:Lyophilized
- Antigen synonyms:Brain-derived neurotrophic factor|proBDNF|Abrineurin
- Immunogen:Recombinant human BDNF
- Cat. no.:10782-616
- Supplier No.:S-015-500
Specifications
About this item
BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.
A cross reactivity of less than 1% against mouse NGF, recombinant human NT3 or NT4/5 has been shown by one site ELISA.
Application Information:
IHC, ELISA, WB, inhibition of biological activity in vitro/in vivo. Recommended to be used at an amount of 1-10 µg/ml for immunohistochemistry, ELISA, Western blot or inhibition of biological activity in vitro. Use neat for in vivo studies at 2-10 µg/ml (ED50). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: rh BDNF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: [delete]
Host: Sheep
Isotype: IgG
Reactivity: Human, Rat