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Specifications
- Antibody type:Primary
- Antigen name:Brain-derived Neurotrophic Factor Precursor
- Clonality:Polyclonal
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:ProBDNF
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:20 µg
- Western blot:Yes
- Epitope:69-82 aa
- Cross adsorption:No
- Format:Lyophilized
- Antigen synonyms:pro BDNF|Brain-derived neurotrophic factor precursor|proBDNF
- Immunogen:A synthetic peptide (C-ELLDEDQKVRPNEE) as a part of human BDNF precursor protein (aa: 69-82) conjugated to KLH has been used as the immunogen.
- Cat. no.:10782-594
- Supplier No.:R-176-20
Specifications
About this item
BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.
Used in western blot, this antiserum detects a 35 kDa band corresponding to the molecular weight of proBDNF. No cross reactivity with other proneurotrophins was detected.
Application Information:
IHC, WB. 1-5 µg/ml is recommended for both applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: ProBDNF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: 69-82 aa
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat