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Specifications
- Antibody type:Primary
- Antigen name:Myeloperoxidase
- Clonality:Monoclonal
- Clone:4C11F6
- Host:Mouse
- Isotype:IgA
- Reactivity:Human
- Antigen symbol:MPO
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:150 µL
- Western blot:Yes
- Storage buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
- Shipping temperature:Store at -20°C
- Immunogen:Recombinant Protein
- Purification:Protein A Purification
- Cat. no.:10090-372
- Supplier No.:66177-1-IG
Specifications
About this item
The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities. The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains. The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit . Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing.
IHC: Human tonsillitis Tissue, 1:20-1:200; Western Blot: HL-60 Cells, 1:500-1:5000
Type: Primary
Antigen: MPO
Clonality: Monoclonal
Clone: 4C11F6
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgA
Reactivity: Human