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Specifications
- Antibody type:Primary
- Antigen name:CD22 molecule
- Clonality:Monoclonal
- Clone:7A2F1
- Host:Mouse
- Isotype:IgG2a
- Reactivity:Human
- Antigen symbol:CD22
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:150 µL
- Western blot:Yes
- Antigen synonyms:B-lymphocyte cell adhesion molecule|Lyb8|B-cell receptor CD22|BL-CAM|Lyb-8|Siglec-2|A530093D23|Leu-14
- Storage buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
- Shipping temperature:Store at -20°C
- Immunogen:Fusion Protein
- Purification:Protein A Purification
- Cat. no.:10084-298
- Supplier No.:66103-1-IG
Specifications
About this item
CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.
Western Blot: Raji Cells, 1:500-1:5000; IHC: Human Lymphoma, 1:20-1:200
Type: Primary
Antigen: CD22
Clonality: Monoclonal
Clone: 7A2F1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human