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Specifications
- Antibody type:Primary
- Antigen name:Coagulation Factor 12
- Clonality:Monoclonal
- Clone:2E2F11
- Host:Mouse
- Isotype:IgG2b
- Reactivity:Human,Mouse
- Antigen symbol:F12
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:150 µL
- Western blot:Yes
- Antigen synonyms:HAF|Coagulation Factor XII|HAE3|Hageman Factor|HAEX
- Storage buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
- Shipping temperature:Store at -20°C
- Immunogen:Fusion Protein
- Purification:Protein A Purification
- Supplier No.:66089-1-IG
Specifications
About this item
Factor XII (F XII, Hageman factor) is a 80kD, single chain glycoprotein that circulates in blood as an inactive zymogen. F XII plays an important role in blood coagulation, fibrinolysis, and kinin generation. When plasma comes into contact with negatively charged surfaces such as glass, kaolin, or dextran sulfate, F XII is bound to the surface and undergoes limited proteolysis by plasma kallikrein, resulting in two active enzyme forms, ɑ-F XIIa and β-F XIIa. ɑ-F XIIa consisting of a 28kD light chain containing the protease domain, and a 52kD heavy chain containing the anionic surface-binding domain. β-F XIIa consists of two disulfide-linked chains, a 2 kD light chain and a 28 kD heavy chain containing the catalytic domain. Defects in Factor XII do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
Western Blot:K562 Cells, 1:500-1:5000; IHC: Human Liver Tissue, 1:20-1:200; IF: HepG2 Cells, 1:10-1:100
Type: Primary
Antigen: F12
Clonality: Monoclonal
Clone: 2E2F11
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human, Mouse